The dynamics of changes in United States (US) foreign policy are a reflection of global power shifts, domestic challenges and complex geopolitical issues. In recent years, US foreign policy has undergone significant changes influenced by a variety of factors, including presidential elections, economic conditions, and changes in international relations. One of the key moments was the transition from the government of Barack Obama to Donald Trump. Obama’s multilateral and diplomatically oriented policies can be seen in the agreement with Iran and the Paris agreement on climate change. Under Trump’s leadership, the focus shifted to his “America First” policy, which emphasized nationalism and reduced international engagement. Withdrawal from international agreements such as the TPP and the Paris Agreement represents a drastic change in the US approach to the world. In the Biden era, there are efforts to restore a multilateral approach. Biden’s foreign policy includes a focus on diplomacy, cooperation with allies, and attention to global issues such as climate change and human rights. Returning to the Paris agreement demonstrates the US’s commitment to playing a role in addressing global challenges. In addition, US relations with China show a more complex pattern. China’s rise as an economic and military power is a major challenge for the US. Biden’s “Indo-Pacific strategy” policy aims to respond to the expansion of China’s influence, strengthen alliances with countries in the region and highlight the importance of shared defense. The Russo-Ukrainian war that began in 2022 has also changed the US foreign policy landscape. Military and economic support for Ukraine has become a symbol of US support for democracy and opposition to aggression. This step not only serves to help Ukraine, but also as an effort to strengthen NATO and maintain European security stability. Internal challenges, including political polarization, also influence US foreign policy. Discussions regarding the goals and direction of diplomacy are often hampered by differences in views between political parties. Uncertainty regarding the future sustainability of foreign policy is a concern among international allies and partners. Domestic issues, such as climate change and the response to the COVID-19 pandemic, also influence foreign policy. The global economic instability caused by the pandemic shows that security is not only measured by military strength, but also by the ability to face global challenges that have a direct impact on people’s welfare. As a result, the dynamics of US foreign policy do not only revolve around military strategy, but also include economic and diplomatic aspects. Global peace and stability are long-term goals, although approaches to achieving them may vary according to leadership and time context. In facing global challenges such as climate change, pandemics and geopolitical tensions, US foreign policy is expected to adapt and evolve. Efforts to establish productive relations with other countries and fulfill its global responsibilities will be a major challenge in US foreign policy in the future. Exploring the path of diplomacy and international collaboration is the central agenda for responding to the various dynamics that exist in an ever-changing global world.